HIV and Influenza Infection Are Associated with Increased Blood Pneumococcal Load: a Prospective, Hospital-Based Observational Study in South Africa, 2009-2011 Running Title: HIV/influenza increase pneumococcal load
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منابع مشابه
Severe Influenza-associated Respiratory Infection in High HIV Prevalence Setting, South Africa, 2009–2011
Data on influenza epidemiology in HIV-infected persons are limited, particularly for sub-Saharan Africa, where HIV infection is widespread. We tested respiratory and blood samples from patients with acute lower respiratory tract infections hospitalized in South Africa during 2009-2011 for viral and pneumococcal infections. Influenza was identified in 9% (1,056/11,925) of patients enrolled; amon...
متن کاملMortality amongst Patients with Influenza-Associated Severe Acute Respiratory Illness, South Africa, 2009-2013
INTRODUCTION Data on the burden and risk groups for influenza-associated mortality from Africa are limited. We aimed to estimate the incidence and risk-factors for in-hospital influenza-associated severe acute respiratory illness (SARI) deaths. METHODS Hospitalised patients with SARI were enrolled prospectively in four provinces of South Africa from 2009-2013. Using polymerase chain reaction,...
متن کاملEpidemiology of Severe Acute Respiratory Illness (SARI) among Adults and Children Aged ≥5 Years in a High HIV-Prevalence Setting, 2009–2012
OBJECTIVE There are few published studies describing severe acute respiratory illness (SARI) epidemiology amongst older children and adults from high HIV-prevalence settings. We aimed to describe SARI epidemiology amongst individuals aged ≥5 years in South Africa. METHODS We conducted prospective surveillance for individuals with SARI from 2009-2012. Using polymerase chain reaction, respirato...
متن کاملEffectiveness of influenza and pneumococcal vaccines in preventing pneumonia 1 development and hospitalization : a prospective cohort study 2 3 Running title : Influenza and pneumococcal vaccines
24 Pneumonia and acute exacerbation of chronic illness are leading causes of influenza-related 25 hospitalization. Therefore, influenza and pneumococcal vaccinations are strongly 26 recommended for adults with comorbidities. Using a hospital-based influenza surveillance 27 system, we performed a multicenter, prospective cohort study of patients visiting emergency 28 rooms with influenza-like il...
متن کاملGenomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis
OBJECTIVE Bacterial meningitis in sub-Saharan Africa is predominantly caused by Streptococcus pneumoniae, is often associated with HIV co-infection and mortality rates are double those seen in better resourced settings. METHODS To investigate the cause of this excessive mortality we quantified the pneumococcal DNA load and six common pro-inflammatory cytokines in the cerebrospinal fluid (CSF)...
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